HomeScienceGeneticsMigraines caused by changes in metabolite levels: study | Health

Migraines caused by changes in metabolite levels: study | Health

migraine are a pain in the head and hip pocket, but newly discovered genetic causes by QUT researchers may point the way to new preventive drugs and therapies.

The findings of genetic analyzes were published in The American Journal of Human Genetics by Professor Dale Nyholt and his PhD students Hamzeh Tanha and Anita Sathyanarayanan, all from the QUT Center for Genomics and Personalized Health.

Professor Nyholt said the team identified causal genetic links with three levels of blood metabolites increases the risk of migraines: lower levels of DHA, an omega-3 known to reduce inflammation, higher levels of LPE (20:4), a chemical that blocks an anti-inflammatory molecule, lower levels of a third, currently uncharacterized metabolite called X -11315.

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Professor Nyholt said these genetic links could now be the target of future research and clinical trials to develop and test compounds that affect metabolite levels and prevent migraines.

He said migraines cost the Australian economy an estimated $35.7 billion a year and that current treatments have failed up to 50 percent of migraine sufferers.

“Perceived relationships between genetic factors influencing blood metabolite levels and genetic risk of migraine suggest an alteration of metabolites in people with migraine,” said Professor Nyholt.

“Variations in blood levels of metabolites may be due to diet, lifestyle and genetics, but they are easy to measure and can be adjusted with dietary planning and supplementation,” Professor Nyholt said.

Professor Nyholt said people with migraines had higher levels of shorter fatty acids, except for docosahexaenoic acid (DHA), a very long-chain omega-3 that protects against migraines.

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“Fatty acids are composed of more complex lipids that aid in cell signaling, cell membrane composition and gene expression, influencing disease risk,” he said.

“Lower levels of DHA are associated with inflammation, cardiovascular disease and brain disorders, such as depression, all of which are linked to migraine risk.”

Professor Nyholt said LPE (20:4) was a chemical compound that blocked the production of an anti-inflammatory molecule called anandamide.

“If LPE (20:4) is controlled to allow the production of more anandamide to reduce inflammation, it could potentially prevent migraines,” he said.

Professor Nyholt said lower blood levels of a third metabolite called X-11315 also increased migraine risk, and characterizing it was an area of ​​future research.

This story was published from an agency news agency with no edits to the text. Only the headline has been changed.

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